Differential aging of growth plate cartilage underlies differences in bone length and thus helps determine skeletal proportions
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چکیده
منابع مشابه
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Articular and growth plate cartilage both arise from condensations of mesenchymal cells, but ultimately develop important histological and functional differences. Each is composed of three layers-the superficial, mid and deep zones of articular cartilage and the resting, proliferative and hypertrophic zones of growth plate cartilage. The bone morphogenetic protein (BMP) system plays an importan...
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The diverse morphology of vertebrate skeletal system is genetically controlled, yet the means by which cells shape the skeleton remains to be fully illuminated. Here we perform quantitative analyses of cell behaviours in the growth plate cartilage, the template for long bone formation, to gain insights into this process. Using a robust avian embryonic organ culture, we employ time-lapse two-pho...
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induce expression of active proteinases leading to increased matrix degradation. Other fragments increase matrix synthesis and cellular proliferation. Several studies have suggested that type II collagen fragments might influence chondrocyte differentiation in endochondral ossification, and we hypothesise that collagen II fragments might also promote cellular hypertrophy when they are over-prod...
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This paper is the sixth in a series of statistics articles recently published by Australian Critical Care. In this paper we explore the most commonly used statistical tests to compare groups of data at the nominal level of measurement. The chosen statistical tests are the chi-square test, chi-square test for goodness of fit, chi-square test for independence, Fisher's exact test, McNemar's test ...
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ژورنال
عنوان ژورنال: PLOS Biology
سال: 2018
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.2005263